Cytotoxicity of curcumin, taurine and alpha tocopherol acetate on zr-75-1 cell line

Rupal Ramteke; Archana  Moon; Amit Taksande; Tuba  Khan; Rupal  Salwankar; Mohd Vashid  Ansari

doi:10.22376/ijpbs.v16i4.112

Authors

Rupal Ramteke Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.
Archana Moon Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.
Amit Taksande Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.
Tuba Khan Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.
Rupal Salwankar Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.
Mohd. Vashid Ansari Post Graduate Teaching Department of Biochemistry, Laxminarayan Innovation Technological University, Nagpur.

Abstract

Breast cancer continues to be one of the major contributors to cancer-related illness and death across the globe. Although current therapies are effective, they are often associated with significant side effects and invasive treatment protocols. This study explores the cytotoxic potential of three phytochemicals-Taurine, Alpha Tocopherol Acetate (α-TEA), and Curcumin-on ZR-75-1 human breast cancer cell lines, aiming to identify natural compounds that could serve as safer, adjunctive therapeutic options. Using the MTT assay, the effects of varying concentrations of each compound were assessed. Taurine and α-TEA exhibited cytotoxic effects at millimolar concentrations, while Curcumin demonstrated strong anticancer potential at low nanomolar concentrations. These findings support the role of phytochemicals in breast cancer treatment and underscore the need for further research into their mechanisms of action and therapeutic applicability

Keywords:

ZR-75-1 cell line, Taurine, Alpha-tocopherol acetate, curcumin, Cytotoxicity

DOI

https://doi.org/10.22376/ijpbs.v16i4.112

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