Synthesis and evaluation of anti-bacterial activity of benzimidazole derivatives

Abstract

Synthesis of molecules and materials are important aspects of the development of science. In the past, synthesis is based on some of the name reactions in organic and inorganic chemistry. The attempts to synthesis new molecule and materials have always depended on the molecules. The synthesis of heterocyclic compounds has always drawn the attention of chemist over the years mainly because of their important biological properties. To synthesize substituted benzimidazoles from o-phenylene diamine using various acids and amines. Heterocyclic compound previously reported benzimidazole was synthesized by treating o-phenylene diamine with benzoic acid (1a) and o-phenylene diamine with formic acid (1b) in presence of ethanol undergoes condensation to form required 2-substituted benzimidazoles. Latter compound 1 was treated with acid chloride i.e chloro acetyl chloride in presence of base 10% NaOH to yield the respective 1-substituted benzimidazole- chloro derivatives (2a-2b). Finally the formed chloro derivative benzimidazoles were refluxed with different amines (methylamine, diethylamine) at certain time period to yield the title compounds in good yields. The completion of the reactions was monitored by TLC. The synthesized compounds were made pure by means of recrystallization method using different solvent systems like ethanol, chloroform. Substituted benzimidazoles derivatives were synthesized utilizing o-phenylene diamine and substituted acids with amines results in good yields.