PHYTOCHEMICAL BASED STRATEGIES FOR CARDIOVASCULAR RISK REDUCTION: A NARRATIVE REVIEW

Authors

  • Yerva Vyshnavi Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

The cardiovascular diseases (CVDs) continue to be a major cause of morbidity and mortalityin most parts of the corridor, and there is need to research on complementary and alternative modes of treatment. Several medicinal plants have bioactive compo of flavonoid, alkaloids, saponins and polyphenols which possess antioxidant, anti-inflammatory, antihypertensive, hypolipidemic, and antithrombotic properties. Some of the herbs, including Allium sativum (garlic), Terminalia arjuna (hawthorn), etc. have demonstrated potential effects on the cardiac system, blood pressure, serum cholesterol, and vascular conditions.

DOI

https://doi.org/10.70604/jmtbas.v3i2.195

References

1. Wu CH, Wang CC, Tsai MT, Huang WT, Kennedy J. Trend and pattern of herb and supplement use in the United States: results from the 2002, 2007, and 2012 National Health Interview Surveys. Evid Based Complement Alternat Med. 2014;2014:872320. doi:10.1155/2014/872320.

2. Islam SU, Ahmed MB, Ahsan H, Lee YS. Recent molecular mechanisms and beneficial effects of phytochemicals and plant-based whole foods in reducing LDL-C and preventing cardiovascular disease. Antioxidants (Basel). 2021;10(5):784. doi:10.3390/antiox10050784.

3. Sahebkar A, Serban MC, Gluba-Brzózka A, Mikhailidis DP, Cicero AFG, Rysz J, et al. Lipid-modifying effects of nutraceuticals: an evidence-based approach. Nutrition. 2016;32(11-12):1179-1192. doi:10.1016/j.nut.2016.04.007.

4. Yang J, Wang HX, Zhang YJ, Yang YH, Lu ML, Zhang J, et al. Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-κB signaling pathway in isoproterenol-induced myocardial hypertrophy. J Ethnopharmacol. 2013;150(3):1062-1070. doi:10.1016/j.jep.2013.10.017.

5. Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-299. doi:10.1111/nure.12012.

6. Shafiee M, Carbonneau MA, Urban N, Descomps B, Leger CL. Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production: a comparison to other extracts or compounds. Free Radic Res. 2003;37(5):573-584. doi:10.1080/1071576031000083152.

7. Dasgupta A, Kidd L, Poindexter BJ, Bick RJ. Interference of hawthorn on serum digoxin measurements by immunoassays and pharmacodynamic interaction with digoxin. Arch Pathol Lab Med. 2010;134(8):1188-1192. doi:10.5858/2009-0404-OA.1.

8. Surai PF. Silymarin as a natural antioxidant: an overview of the current evidence and perspectives. Antioxidants (Basel). 2015;4(1):204-247. doi:10.3390/antiox4010204.

9. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59. doi:10.1016/j.biocel.2008.06.010.

10. Cuong VT, Chen W, Shi J, Zhang M, Yang H, Wang N, et al. The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans. Exp Gerontol. 2019;117:99-105. doi:10.1016/j.exger.2018.11.016.

11. Nguyen NH, Ha TKQ, Yang JL, Pham HTT, Oh WK. Triterpenoids from the genus Gynostemma: chemistry and pharmacological activities. J Ethnopharmacol. 2021;268:113574. doi:10.1016/j.jep.2020.113574.

12. Bachheti RK, Worku LA, Gonfa YH, Zebeaman M, Deepti, Pandey DP, et al. [Retracted] Prevention and treatment of cardiovascular diseases with plant phytochemicals: a review. Evid Based Complement Alternat Med. 2022;2022:5741198. doi:10.1155/2022/5741198.

13. Louisa M, Patintingan CG, Wardhani BW. Moringa oleifera Lam. in cardiometabolic disorders: a systematic review of recent studies and possible mechanism of actions. Front Pharmacol. 2022;13:792794. doi:10.3389/fphar.2022.792794.

14. Jiang M, Cui BW, Wu YL, Nan JX, Lian LH. Genus Gentiana: a review on phytochemistry, pharmacology and molecular mechanism. J Ethnopharmacol. 2021;264:113391. doi:10.1016/j.jep.2020.113391.

15. Tolouei SE, Tirloni CAS, Palozi RAC, Schaedler MI, Guarnier LP, Silva AO, et al. Celosia argentea L. (Amaranthaceae), a vasodilator species from the Brazilian Cerrado: an ethnopharmacological report. J Ethnopharmacol. 2019;229:115-126. doi:10.1016/j.jep.2018.09.027.

16. Nauman MC, Johnson JJ. Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers. Integr Food Nutr Metab. 2019;6(2):1-6. doi:10.15761/IFNM.1000249.

17. González-Rámila S, Sarriá B, Seguido MÁ, García-Cordero J, Bravo-Clemente L, Mateos R. Effect of olive pomace oil on cardiovascular health and associated pathologies. Nutrients. 2022;14(19):3927. doi:10.3390/nu14193927.

18. Cicero AFG, Colletti A, Bajraktari G, Descamps O, Djuric DM, Ezhov M, et al. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutr Rev. 2017;75(9):731-767. doi:10.1093/nutrit/nux047.

19. Dauncey EA, Irving JT, Allkin R. A review of issues of nomenclature and taxonomy of Hypericum perforatum L. and Kew's Medicinal Plant Names Services. J Pharm Pharmacol. 2019;71(1):4-14. doi:10.1111/jphp.12831.

20. Clobes TA. –Complementary and Integrative Healing Modalities. Introduction to the US Healthcare System-Second Edition.

21. Chow SL, Bozkurt B, Baker WL, Bleske BE, Breathett K, Fonarow GC, et al. Complementary and alternative medicines in the management of heart failure: a scientific statement from the American Heart Association. Circulation. 2023;147(2):e4-e30. doi:10.1161/CIR.0000000000001110.

22. Li X, Yu T, Jiang Q, Tan J, Liu K. The efficacy of traditional Chinese herbal medicine across multiple cardiovascular diseases: an umbrella review of systematic reviews of randomized controlled trials. J Cardiovasc Pharmacol. 2024;83(4):340-352. doi:10.1097/FJC.0000000000001535.

23. Kolapudi RK, Kapudasi J, Koppula SB, Chandu B. Stem Cells Treatment for the Future Heart Diseases. Drug Invention Today. 2012 Jun 1;4(6). p. 388

24. Prasanthi G, Chandu Baburao CB, Kumar YP, Swarnalatha D, Gopinath C. Chemical pharmacology of Khat leaves.

25. Suryasagar G, Bhargavi S, Kanakaiah B, Sowmya DK, Naresh M, Nama S, et al. A review on resealed erythrocytes. Int J Biol Pharm Res. 2013;4:290-296.

26. Dey B, Hwisa NT, Khalf AM, Mitra A, Katakam P, Rao CB. Pharmaco-epidemiological studies on self medication and drug utilization pattern in chronic diseases via prescription auditing. Int J Sci Res Knowl. 2013;1(11):464-471. doi:10.12983/ijsrk-2013-p464-471.

27. Buchiraju R, Nama S, Sakala B, Chandu BR, Kommu A, Chebrolu JK, Yedulapurapu N. Vesicular drug delivery system: an overview. Res J Pharm Biol Chem Sci. 2013;4(3):462-474.

28. Deepthi BV, Varun D, Gopal PN, Rao CB, Sumalatha G. Super porous hydrogels: supreme drug delivery. Res J Pharm Technol. 2011;4(8):1182-1188.

29. Babu Rao CH, Padma S, Niveditha W, Ramakrishna R, Gupta J, Vardhan A. Formulation and in vitro evaluation of carvedilol tablets. Indian Pharmacist. 2007;6(60):77-78.

30. GP B, Desu PK, Rao CB. STAR POLYMERS: AN OVERVIEW. 2013; 4(2): 76-79.

Published

2026-06-20
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Yerva, V. (2026). PHYTOCHEMICAL BASED STRATEGIES FOR CARDIOVASCULAR RISK REDUCTION: A NARRATIVE REVIEW. Journal of Modern Techniques in Biology and Allied Sciences, 3(2), 27-32. https://doi.org/10.70604/jmtbas.v3i2.195

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How to Cite

Yerva, V. (2026). PHYTOCHEMICAL BASED STRATEGIES FOR CARDIOVASCULAR RISK REDUCTION: A NARRATIVE REVIEW. Journal of Modern Techniques in Biology and Allied Sciences, 3(2), 27-32. https://doi.org/10.70604/jmtbas.v3i2.195