Case study on herpes zoster
Abstract
Reactivation of the varicella- zoster virus (VZV), which is dormant in sensory ganglia following first infection, is the cause of herpes zoster, also known as shingles. It appears as a dermatomal pattern of painful unilateral vesicular rash. Age, Immunosuppression, stress and long- term illness are risk factors. Variants including Ramsay Hunt Syndrome, herpes zoster Ophthalmicus, and have unique side effects like neuropathic pain and visual loss. The primary Method of diagnosis is clinical, albeit in atypical circumstances, PCR or direct fluorescent antibody testing may be used. Acyclovir, Valacyclovir, or Famciclovir used as early antiviral therapy lessens severity, The best preventive Method is still vaccination, which is advised for e everyone.
Keywords:
Varicella-zoster virus (VZV), Herpes zoster (shingles), Dermatomal rash, Risk factors, Antiviral therapy, VaccinationDOI
https://doi.org/10.70604/jmtbas.v1i2.32References
1. John AR, Canaday DH. Herpes Zoster in the Older Adult. Infect Dis Clin North Am. 2017 Dec;31(4):811-826. doi: 10.1016/j.idc.2017.07.016. PMID: 29079160; PMCID: PMC5724974.
2. Heineman TC, Cunningham A, Levin M. Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine. CurrOpinImmunol. 2019 Aug;59:42-48. [PubMed]
3. Watanabe D. [Cutaneous Herpesvirus Infection]. Brain Nerve. 2019 Apr;71(4):302-308. [PubMed]
4. Yu YH, Lin Y, Sun PJ. Segmental zoster abdominal paresis mimicking an abdominal hernia: A case report and literature review. Medicine (Baltimore). 2019 Apr;98(15):e15037. [PMC free article] [PubMed]
5. Yamaoka-Tojo M, Tojo T. Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination. Vaccines. 2024 Mar;12(3):252
6. Standardization of Uveitis Nomenclature (SUN) Working Group (2021). Classification Criteria for Varicella Zoster Virus Anterior Uveitis. American journal of ophthalmology, 228, 165–173. https://doi.org/10.1016/j.ajo.2021.03.037
7. Dayan, R. R., & Peleg, R. (2017). Herpes zoster - typical and atypical presentations. Postgraduate medicine, 129(6), 567–571. https://doi.org/10.1080/00325481.2017.1335574
8. Tung, Y. C., Tu, H. P., Wu, M. K., Kuo, K. L., Su, Y. F., Lu, Y. Y., Lin, C. L., & Wu, C. H. (2020). Higher risk of herpes zoster in stroke patients. PloS one, 15(2), e0228409. https://doi.org/10.1371/journal.pone.0228409
9. Wung PK, Holbrook JT, Hoffman GS, Tibbs AK, Specks U, et al. Herpes zoster in immunocompromised patients: incidence, timing, and risk factors. Am J Med. 2005 Dec. 118(12):1416. [QxMD MEDLINE Link].
10. Norman J, Politz D. Shingles (varicella zoster) outbreaks in patients with hyperparathyroidism and their relationship to hypercalcemia. Clin Infect Dis. 2008 May 1. 46(9):1452-4. [QxMD MEDLINE Link].
11. Johannsen EC, Kaye KM: Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases). In Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Ninth Edition), Elsevier, 2020, pp. 138, 1872-1890, 2020 . ISBN: 9996119890, 9789996119897
12. Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J ClinVirol. 2010 May;48 Suppl 1(Suppl 1):S2-7. doi: 10.1016/S1386-6532(10)70002-0. PMID: 20510263; PMCID: PMC5391040.
13. Ongkosuwito JV, Feron EJ, van Doornik CE, Van der Lelij A, Hoyng CB, La Heij EC, et al. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Invest Ophthalmol Vis Sci. 1998 Dec. 39(13):2659-65. [QxMD MEDLINE Link].
14. Kumano Y, Manabe J, Hamamoto M, Kawano Y, Minagawa H, Fukumaki Y, et al. Detection of varicella-zoster virus genome having a PstI site in the ocular sample from a patient with acute retinal necrosis. Ophthalmic Res. 1995. 27(5):310-6. [QxMD MEDLINE Link].
15. Karlin JD. Herpes zoster ophthalmicus: the virus strikes back. Ann Ophthalmol. 1993 Jun. 25(6):208-15. [QxMD MEDLINE Link].
16. Baumrin E, Van Voorhees A, Garg A, Feldman SR, Merola JF. A systematic review of herpes zoster incidence and consensus recommendations on vaccination in adult patients on systemic therapy for psoriasis or psoriatic arthritis: From the Medical Board of the National Psoriasis Foundation. J Am AcadDermatol. 2019 Jul;81(1):102-110. [PubMed]
17. Miles LW, Williams N, Luthy KE, Eden L. Adult Vaccination Rates in the Mentally Ill Population: An Outpatient Improvement Project. J Am Psychiatr Nurses Assoc. 2020 Mar/Apr;26(2):172-180. [PubMed]
18. Rooney BV, Crucian BE, Pierson DL, Laudenslager ML, Mehta SK. Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth. Front Microbiol. 2019;10:16. [PMC free article] [PubMed]
19. Lim DZJ, Tey HL, Salada BMA, Oon JEL, Seah ED, Chandran NS, Pan JY. Herpes Zoster and Post-Herpetic Neuralgia-Diagnosis, Treatment, and Vaccination Strategies. Pathogens. 2024 Jul 17;13(7):596. doi: 10.3390/pathogens13070596. PMID: 39057822; PMCID: PMC11280284.
20. Patil A, Goldust M, Wollina U. Herpes zoster: A Review of Clinical Manifestations and Management. Viruses. 2022 Jan 19;14(2):192. doi: 10.3390/v14020192. PMID: 35215786; PMCID: PMC8876683.
21. Bader MS. Herpes zoster: diagnostic, therapeutic, and preventive approaches. Postgrad Med. 2013 Sep;125(5):78-91. doi: 10.3810/pgm.2013.09.2703. PMID: 24113666.
22. Bader M. S. (2013). Herpes zoster: diagnostic, therapeutic, and preventive approaches. Postgraduate medicine, 125(5), 78–91. https://doi.org/10.3810/pgm.2013.09.2703
23. Opstelten W, Eekhof J, Neven AK, Verheij T. Treatment of herpes zoster. Can Fam Physician. 2008 Mar;54(3):373-7. PMID: 18337531; PMCID: PMC2278354.
24. Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J DermatolVenereolLeprol 2018;84:251-262
25. Johnson RW, Dworkin RH. Treatment of herpes zoster and postherpetic neuralgia. BMJ. 2003 Apr 5;326(7392):748-50. Doi: 10.1136/bmj.326.7392.748. PMID: 12676845; PMCID: PMC1125653.
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