Synthesis and characterization of few 1,4-dihydro pyridines and their in silico prediction
Abstract
Heterocyclic compounds form the largest of classical divisions of organic chemistry and are of immense importance biologically and industrially. 1,4-Dihydropyridines are an important class of compounds with a wide range of biological activities. Dihydropyridines were reported for their antitumor, calcium channel blokers, antitubercular, analgesic, antithrombotic, anti-inflammatory, acaricidal, insecticidal, bactericidal, anticonvulsant and other pharmacological activities. Keeping this in view, it was proposed to synthesize some new dihydropyridine derivatives by conventional method. All the synthesized compounds were characterized by FT-IR, and1H NMR spectral studies and their structures were established. All the synthesized compounds were predicted for biological properties by using PASS (Prediction of Activity Spectrum of Substances) computer program. The results of these predictions are given in PASS computer program predicts all title compounds. All the title compounds were synthesized, characterized and screened for their antihypertensive activity.
Keywords:
Heterocyclic compounds, 1,4-Dihydropyridines, FT-IR, and 1H NMR, PASS computer program, antihypertensive activityDOI
https://doi.org/10.70604/References
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