To study the prevalence of malaria and to determine the efficacy of prepared niosomes for combinatorial drug delivery of anti malarial drugs
Abstract
BACKGROUND: Malaria is a caused by parasites that are transmitted through bites of Anopheles mosquitoes. AIM: The aim of the study is to assess the prevalence of malaria in the tertiary care hospital during the study period of 6 months. METHODS: This a retrospective observational study conducting in both inpatients and outpatients diagnosed with malaria considering different age groups and other disease conditions. Data including the demographic details were obtained by medical history interview and niosomal formulation was subjected with the help of various suitable materials. RESULTS & DISCUSSION: 30 patients were admitted in the department of general medicine. The results were obtained from 30 patients with malaria disease who are enrolled in the study fulfilled after selection criteria on obtaining consent from the same among 30 patients. Peak prevalence of malaria occurred between the age group of 20-30.The total no. Of patients with malaria associated with hypertension and diabetes in males of age group between 20-60 was found to be 60% and females of age group between 20-60 was found to be 40%. Prevalence of stage–1(53%)is highest among the population. CONCLUSION: In this study, total 30 cases (n=30)were collected who have been diagnosed with malaria from the tertiary care hospital and studied the prevalence of occurrence of malaria between age groups and gender bias and prevalence of risk factors associated with malaria. The prepared niosomal drug delivery system and characterization was done and particle size (Span20˂ Brij35< tween 20<Tween 80), stability parameter, TEM & in vitro studies were performed in dialysis bag taking tween 80, tween 20, span 20, brij 35 niosomes and drug (primaquine) was compared by using RP-HPLC technique. The drug loaded niosomal preparations are effective for tween-80 niosomes for treatment of malaria.
Keywords:
Malaria, Niosomal preparations, RP-HPLC technique, Non-ionic surfactants, Pharmaceutical preparationsDOI
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