AN OVER VIEW OF GASTRO-RETENTIVE FLOATING DOSAGE FORM AND THEIR CLINICAL SIGNIFICATION

Abstract

The purpose of writing review on Gastro-Retentive floating Dosage System (GRFDS) was to compile the recent literature with specific focus on the principal mechanism of floatation to achieve gastric retention. These systems are useful to overcome several problems encountered during the development of a pharmaceutical dosage form. Oral route of drug administration is the most convenient route and accepted route of drug delivery. It is probable that at least 90% of all the drugs given by oral route. There are different drug deliveries to cure the diseases through oral route. Among them Gastro-retentive drug delivery system plays an important and significant role in novel drug delivery systems. The floating systems, bio adhesive drug delivery system, expandable drug delivery system, high density systems, effervescent systems (Gas Generating systems), non-effervescent systems etc. are various approaches. The wide applications can be achieved through this delivery system are enhanced bioavailability, sustained drug delivery, site-specific drug delivery, absorption enhancement, mitigating adversity at colon etc. In addition to specified above, the advantages and disadvantages, drugs and polymers used and the method of evaluation is also summarized in this review. The most current advancements in GRFDS are reviewed in depth, along with the physiological factors and formulation factors impacting stomach retention, design strategies for single-unit and multiple-unit floating systems and their classification. The advantages and future prospects for drug delivery of the present technological breakthroughs of GRFDS.