A REVIEW ON: ELECTROSTATIC CATALYSIS OF ADIELS-ALDER REACTION
Abstract
Electrostatic catalysis has emerged as a powerful and innovative approach in modern chemical transformations, offering a non-traditional pathway to accelerate reactions without the direct involvement of conventional chemical catalysts.The presence of oriented electric fields can stabilize transition states, influence charge distribution, and lower activation energy barriers, thereby enhancing reaction rates. Recent theoretical and experimental advancements demonstrate how external electric fields and charged environments can mimic enzymatic conditions, providing precise control over reaction pathways. The Diels–Alder reaction is one of the most widely studied pericyclic reactions, known for its ability to form six-membered cyclic compounds through a concerted [4+2] cycloaddition between a diene and a dienophile. This reaction plays a crucial role in the synthesis of natural products, pharmaceuticals, and advanced materials due to its high regioselectivity and stereospecificity.
Keywords:
Electrostatic catalysis, Diels–Alder reaction, cyclic compounds, Aliphatic compoundsReferences
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